SALL4 as a transcriptional and epigenetic regulator in normal and leukemic hematopoiesis
نویسندگان
چکیده
منابع مشابه
TET2 as an epigenetic master regulator for normal and malignant hematopoiesis
DNA methylation is one of the critical epigenetic modifications regulating various cellular processes such as differentiation or proliferation, and its dysregulation leads to disordered stem cell function or cellular transformation. The ten-eleven translocation (TET) gene family, initially found as a chromosomal translocation partner in leukemia, turned out to be a key enzyme for DNA demethylat...
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The cAMP response element-binding protein (CREB) is a nuclear transcription factor downstream of cell surface receptors and mitogens that is critical for normal and neoplastic hematopoiesis. Previous work from our laboratory demonstrated that a majority of patients with acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) overexpress CREB in the bone marrow. To understand the role of ...
متن کاملCREB is a critical regulator of normal hematopoiesis and leukemogenesis.
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ژورنال
عنوان ژورنال: Biomarker Research
سال: 2018
ISSN: 2050-7771
DOI: 10.1186/s40364-017-0115-6